VIDEO: Chelsea Handler Hopes Kate Gosselin's 15 Minutes Of Fame is Up

In what has to be the most hilarious episode of Larry King Live ever, comedian Chelsea Handler's sharp tongue targets Kate Gosselin and other newsmakers. RadarOnline.com has the video with the best highlights from Thursday night.

EXCLUSIVE VIDEO INTERVIEW: Kate Gosselin Still Standing On Dancing With The Stars

The host of E!'s Chelsea Lately said "I don't like people that are famous because of something like that--because she had a lot of children. She doesn't seem like the nicest person in the world. And I don't know what kind of mother that has that many children--I don't know how many children she's up to right now--would have time to be on Dancing With The Stars. Because from what I hear, the rehearsals are pretty laborious. It's like 4-6 hours a day. You have 8 children that's pretty important."

PHOTOS: Kate And Tony Go Cruising

Chelsea, who is promoting a new book Chelsea Chelsea Bang Bang went on to say "I think it's important to make sure people have their 15 minutes then let them go.' But Chelsea pointed out,  "She's gotten a lot of minutes.. so hopefully they're up."

EXCLUSIVE VIDEO INTERVIEW: Pam Anderson's Stylist Slams Kate's Do

When asked why she turned down Dancing With The Stars, Chelsea quipped, "I have a job, I didn't really need to do that!"

PHOTOS: Kate Spends Time With Kids During Break

Larry King also asked her about her feud with the woman who exposed the Jesse James Cheating Scandal: Michelle "Bombshell" McGee.  It started when Chelsea joked on her show: "I guess she doesn't read magazines, because she basically has one on her face." McGee was so upset, she took her anger to Facebook,  "Use some of that botox from your forehead and put it in your flabby underarm skin I've seen better wings in a bucket of KFC chicken."

PHOTOS: Michelle "Bombshell" McGee's Naughty Photos

Chelsea stood up for herself saying " the show (Chelsea Lately) is silly. I like to poke fun at myself and poke fun at others. So when someone like that makes a comment about me I like to stand up for myself. I'm outspoken and I'm a comedian. So you shouldn't really say anything to me unless you're ready to hear it back."

PHOTOS: Celebrity Cheaters Gallery

When asked if she would have McGee on her show. She said "No."

"it's like Heidi and Spencer Montag or Pratt whatever their names are.. who i call herpes 1 and herpes 2. i really wouldn't want them on the show either. I just don't think it speaks volumes about the kind of  person i am. it's a silly show, but it's not a gross show."

PHOTOS: Heidi Montag Post Plastic Surgery

And, she couldn't help weighing in on the Sandra Bullock marriage crisis. She said "It's like something's going around," because of the Tiger Woods and Jesse James scandals. "It's like people are hornier than ever."

Chelsea said keeping up with reality shows and celebrity scandals is putting her IQ in question, "You feel like your brain is melting."

Jesse James Mistress Blasts Chelsea Handler

She has her sights on Larry's CNN job: "So hopefully you'll retire soon so I can take over a job like this.  If I have to talk about Kate Gosselin for one more year, I'll probably shoot myself in the head.'

• Food For Your Face: Lush Fresh Farmacy
• PHOTOS: Kendra Wilkinson On Target During Easter Shopping Spree

• TAGS
• Chelsea Handler
• Chelsea Lately
• CNN
• Dancing With the Stars
• E!
• Heidi Montag
• Kate Gosselin
• Larry King
• Larry King Live
• Michelle Bombshell McGee
• Speidi
• Spencer Pratt