Another Hollywood marriage bites the dust.

Actress Penelope Ann Miller -- who’s been enjoying a career resurgence, thanks to her role in The Artist -- is splitting from her husband of nearly 12 years.

Miller,  48, filed for legal separation on March 14 from James Huggins, citing irreconcilable differences, according to docs filed in the L.A. Superior Court.

Jennifer Aniston and Justin Theroux skipped doing the red carpet together -- she walked it solo --  but we found them inside at the 2012 Directors Guild of America Awards Saturday night, and they couldn't keep their hands off each other.

The romantic duo were hand-in-hand or with arms around each other the entire night.

PHOTOS: Jennifer Aniston And Justin Theroux At The 2012 DGA Awards

Jennifer never looked happier, and dazzled in a black beaded strapless Dolce and Gabbana dress and Fred Leighton's diamond fringe pendant earrings and 13.0 carat rose-cut diamond and platinum ring.

Helen Mirren was there with her director hubby Taylor Hackford. George Clooney and his Descendents director Alexander Payne made it a guys night out.

Michelle Williams wore a Chanel couture gown, and sparkled in diamond jewels by Fred Leighton for Forevermark- diamond stud earrings  and a pair of diamond line and black cord bracelets.

Jon Favreau, Penelope Ann Miller, Amber Heard and Laura Dern were some of the other stars who turned out for the glamorous at the Hollywood & Highland Center.