Katie Couric and her boyfriend Brooks Perlin have broken up after five years of dating.

The couple met at a cancer research fundraising event in 2006, but now the 37-year-old Perlin is moving out of Katie’s Upper East Side townhouse. 

The 54-year-old former CBS Evening News anchor initiated the breakup, according to Us Weekly.  “Brooks is a nice guy, but it was inevitable because they had different priorities and perspectives, and their age difference made it a challenge too.”

When Katie Couric wraps the CBS Evening News broadcast Thursday night, she'll be making news herself.

PHOTOS:  Katie Couric Through The Years

It will be Couric's last appearance at CBS, the end of a run that made her -- on September 5, 2006 -- the first weeknight solo female anchor at any of the "Big Three" networks.