An era ended Friday, as iconic talk show host Regis Philbin made his final appearance after 28 years on his long-running ABC morning show, where he was serenaded with a heartwarming speech from co-host Kelly Ripa.

Kelly said that the 43 steps she took with Regis from the dressing room to the studio floor daily made for a life-changing journey and you can see her entire speech on RadarOnline.com.

"As I was reflecting, and we were taking our final 43 steps together, I thought back to our first 43 steps and I was absolutely terrified -- absolutely filled with fear -- and you grabbed my hand and we walked down the hallway, came out the door...and you did something for me,” Kelly said.

Television queen and daily staple for the last 25 years, Oprah Winfrey taped her final show Tuesday afternoon.

In an audience filled with handpicked fans dressed in brightly-colored outfits, Oprah said goodbye to the nation’s most popular daytime talk show.

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